2024

M. G. Mohsen, Midy, M. K., Balaji, A., and Breaker, R. R., “Engineered Branaplam Aptamers Exploit Structural Elements from Natural Riboswitches”, ACS Chem. Biol., 2024. [Link]
M. G. Mohsen and Breaker, R. R., “Prospects for Riboswitches in Drug Development”, RNA as a Drug Target: The Next Frontier for Medicinal Chemistry, pp. 203-226, 2024.
C. M. Fernando and Breaker, R. R., “Bioinformatic prediction of proteins relevant to functions of the bacterial OLE ribonucleoprotein complex”, mSphere, 2024. [Link]
A. Narunsky, Higgs, G., Torres, B. M., Yu, D., de Andrade, G. Belem, Kavita, K., and Breaker, R. R., “The discovery of novel noncoding RNAs in 50 bacterial genomes”, Nucleic Acids Res., 2024. [Link]
S. E. Lyon, Wencker, F. D. R., Fernando, C. M., Harris, K. A., and Breaker, R. R., “Disruption of the bacterial OLE RNP complex impairs growth on alternative carbon sources”, PNAS Nexus, vol. pgae075, 2024. [Link]
L. W. Soares, King, C. G., Fernando, C. M., Roth, A., and Breaker, R. R., “Genetic disruption of the bacterial raiA motif noncoding RNA causes defects in sporulation and aggregation”, Proc. Natl. Acad. Sci. U. S. A., vol. 121, 2024. [Link]

2023

H. Salvail, Balaji, A., Roth, A., and Breaker, R. R., “A spermidine riboswitch class in bacteria exploits a close variant of an aptamer for the enzyme cofactor S-adenosylmethionine”, Cell Reports, vol. 42, 2023. [Link]
S. Hamal Dhakal, Kavita, K., Panchapakesan, S. S. S., Roth, A., and Breaker, R. R., “8-oxoguanine riboswitches in bacteria detect and respond to oxidative DNA damage”, Proc. Natl. Acad. Sci. U. S. A., vol. 120, 2023. [Link]
R. R. Breaker, Harris, K. A., Lyon, S. E., Wencker, F. D. R., and Fernando, C. M., “Evidence that OLE RNA is a component of a major stress-responsive ribonucleoprotein particle in extremophilic bacteria”, Mol. Microbiol., 2023. [Link]
M. G. Mohsen and Breaker, R. R., “In vitro Selection and in vivo Testing of Riboswitch-inspired Aptamers”, Bio-protocol, vol. 13, 2023. [Link]
H. Salvail and Breaker, R. R., “Riboswitches”, Curr Biol., vol. 33, pp. R343-R348, 2023. [Link]
A. Narunsky, Kavita, K., Panchapakesan, S. S. S., Fris, M. E., and Breaker, R. R., “A conserved uORF in the ilvBNC mRNA of Corynebacterium species regulates ilv operon expression”, Microb. Genom., vol. 9, 2023. [Link]
H. Sadeeshkumar, Balaji, A., Sutherland, A. G., Mootien, S., Anthony, K. G., and Breaker, R. R., “Screening for small molecule inhibitors of SAH nucleosidase using an SAH riboswitch”, Anal. Biochem, 2023. [Link]
M. G. Mohsen, Midy, M. K., Balaji, A., and Breaker, R. R., “Exploiting natural riboswitches for aptamer engineering and validation”, Nucleic Acids Res., vol. 51, pp. 966–981, 2023. [Link]

2022

S. E. Lyon, Harris, K. A., Odzer, N. B., Wilkins, S. G., and Breaker, R. R., “Ornate, large, extremophilic (OLE) RNA forms a kink turn necessary for OapC protein recognition and RNA function”, J. Biol. Chem., vol. 298, no. 12, 2022. [Link]
N. A. White, Sadeeshkumar, H., Sun, A., Sudarsan, N., and Breaker, R. R., “Lithium-sensing riboswitch classes regulate expression of bacterial cation transporter genes”, Sci. Rep., vol. 12, no. 1, 2022. [Link]
M. E. Sherlock, Higgs, G., Yu, D., Widner, D. L., White, N. A., Sudarsan, N., Sadeeshkumar, H., Perkins, K. R., Arachchilage, G. Mirihana, Malkowski, S. N., King, C. G., Harris, K. A., Gaffield, G., Atilho, R. M., and Breaker, R. R., “Architectures and complex functions of tandem riboswitches”, RNA Biol., vol. 19, pp. 1059-1076, 2022. [Link]
K. Kavita and Breaker, R. R., “Discovering riboswitches: the past and the future”, Trends Biochem Sci, 2022. [Link]
N. A. White, Sadeeshkumar, H., Sun, A., Sudarsan, N., and Breaker, R. R., “Na+ riboswitches regulate genes for diverse physiological processes in bacteria”, Nat. Chem. Biol., vol. 18, 2022. [Link]
S. Dhakal, Panchapakesan, S. S. S., Slattery, P., and Breaker, R. R., “Variants of the guanine riboswitch class exhibit altered ligand specificities for xanthine, guanine, or 2′-deoxyguanosine”, Proc. Natl. Acad. Sci. U. S. A., 2022. [Link]

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