2025

K. M. Barth, Hiller, D. A., de Andrade, G. Belem, Kavita, K., Fernando, C. M., Breaker, R. R., and Strobel, S. A., “Decoding the Complex Functional Landscape of the ykkC Riboswitches”, Biochemistry, 2025. [Link]

2024

F. D. R. Wencker, Lyon, S. E., and Breaker, R. R., “Improved methods for genetic manipulation of the alkaliphile Halalkalibacterium halodurans”, Front. Microbiol., vol. 15, 2024. [Link]
M. G. Mohsen, Midy, M. K., Balaji, A., and Breaker, R. R., “Engineered Branaplam Aptamers Exploit Structural Elements from Natural Riboswitches”, ACS Chem. Biol., 2024. [Link]
M. G. Mohsen and Breaker, R. R., “Prospects for Riboswitches in Drug Development”, RNA as a Drug Target: The Next Frontier for Medicinal Chemistry, pp. 203-226, 2024.
C. M. Fernando and Breaker, R. R., “Bioinformatic prediction of proteins relevant to functions of the bacterial OLE ribonucleoprotein complex”, mSphere, 2024. [Link]
A. Narunsky, Higgs, G., Torres, B. M., Yu, D., de Andrade, G. Belem, Kavita, K., and Breaker, R. R., “The discovery of novel noncoding RNAs in 50 bacterial genomes”, Nucleic Acids Res., 2024. [Link]
S. E. Lyon, Wencker, F. D. R., Fernando, C. M., Harris, K. A., and Breaker, R. R., “Disruption of the bacterial OLE RNP complex impairs growth on alternative carbon sources”, PNAS Nexus, vol. pgae075, 2024. [Link]
L. W. Soares, King, C. G., Fernando, C. M., Roth, A., and Breaker, R. R., “Genetic disruption of the bacterial raiA motif noncoding RNA causes defects in sporulation and aggregation”, Proc. Natl. Acad. Sci. U. S. A., vol. 121, 2024. [Link]

2023

H. Salvail, Balaji, A., Roth, A., and Breaker, R. R., “A spermidine riboswitch class in bacteria exploits a close variant of an aptamer for the enzyme cofactor S-adenosylmethionine”, Cell Reports, vol. 42, 2023. [Link]
S. Hamal Dhakal, Kavita, K., Panchapakesan, S. S. S., Roth, A., and Breaker, R. R., “8-oxoguanine riboswitches in bacteria detect and respond to oxidative DNA damage”, Proc. Natl. Acad. Sci. U. S. A., vol. 120, 2023. [Link]
R. R. Breaker, Harris, K. A., Lyon, S. E., Wencker, F. D. R., and Fernando, C. M., “Evidence that OLE RNA is a component of a major stress-responsive ribonucleoprotein particle in extremophilic bacteria”, Mol. Microbiol., 2023. [Link]
M. G. Mohsen and Breaker, R. R., “In vitro Selection and in vivo Testing of Riboswitch-inspired Aptamers”, Bio-protocol, vol. 13, 2023. [Link]
H. Salvail and Breaker, R. R., “Riboswitches”, Curr Biol., vol. 33, pp. R343-R348, 2023. [Link]
A. Narunsky, Kavita, K., Panchapakesan, S. S. S., Fris, M. E., and Breaker, R. R., “A conserved uORF in the ilvBNC mRNA of Corynebacterium species regulates ilv operon expression”, Microb. Genom., vol. 9, 2023. [Link]
H. Sadeeshkumar, Balaji, A., Sutherland, A. G., Mootien, S., Anthony, K. G., and Breaker, R. R., “Screening for small molecule inhibitors of SAH nucleosidase using an SAH riboswitch”, Anal. Biochem, 2023. [Link]
M. G. Mohsen, Midy, M. K., Balaji, A., and Breaker, R. R., “Exploiting natural riboswitches for aptamer engineering and validation”, Nucleic Acids Res., vol. 51, pp. 966–981, 2023. [Link]

2022

S. E. Lyon, Harris, K. A., Odzer, N. B., Wilkins, S. G., and Breaker, R. R., “Ornate, large, extremophilic (OLE) RNA forms a kink turn necessary for OapC protein recognition and RNA function”, J. Biol. Chem., vol. 298, no. 12, 2022. [Link]
N. A. White, Sadeeshkumar, H., Sun, A., Sudarsan, N., and Breaker, R. R., “Lithium-sensing riboswitch classes regulate expression of bacterial cation transporter genes”, Sci. Rep., vol. 12, no. 1, 2022. [Link]
M. E. Sherlock, Higgs, G., Yu, D., Widner, D. L., White, N. A., Sudarsan, N., Sadeeshkumar, H., Perkins, K. R., Arachchilage, G. Mirihana, Malkowski, S. N., King, C. G., Harris, K. A., Gaffield, G., Atilho, R. M., and Breaker, R. R., “Architectures and complex functions of tandem riboswitches”, RNA Biol., vol. 19, pp. 1059-1076, 2022. [Link]
K. Kavita and Breaker, R. R., “Discovering riboswitches: the past and the future”, Trends Biochem Sci, 2022. [Link]

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