2023

M. Mohsen, Midy, M., Balaji, A., and Breaker, R., “Exploiting natural riboswitches for aptamer engineering and validation”, Nucleic Acids Res, 2023. [Link]
H. Sadeeshkumar, Balaji, A., Sutherland, A. G., Mootien, S., Anthony, K. G., and Breaker, R., “Screening for small molecule inhibitors of SAH nucleosidase using an SAH riboswitch”, Anal. Biochem, 2023. [Link]

2022

S. Lyon, Harris, K. A., Odzer, N., Wilkins, S. G., and Breaker, R. R., “Ornate, large, extremophilic (OLE) RNA forms a kink turn necessary for OapC protein recognition and RNA function”, J. Biol. Chem., vol. 298, no. 12, 2022. [Link]
N. White, Sadeeshkumar, H., Sun, A., Sudarsan, N., and Breaker, R. R., “Lithium-sensing riboswitch classes regulate expression of bacterial cation transporter genes”, Sci. Rep., vol. 12, no. 1, 2022. [Link]
K. Kumari and Breaker, R. R., “Discovering riboswitches: the past and the future”, Trends Biochem Sci, 2022. [Link]
N. White, Sadeeshkumar, H., Sun, A., Sudarsan, N., and Breaker, R., “Na+ riboswitches regulate genes for diverse physiological processes in bacteria”, Nature Chem Bio, vol. 18, 2022. [Link]
S. Dhakal, Panchapakesan, S. S. S., Slattery, P., and Breaker, R. R., “Variants of the guanine riboswitch class exhibit altered ligand specificities for xanthine, guanine, or 2′-deoxyguanosine”, PNAS, 2022. [Link]
R. R. Breaker, “The Biochemical Landscape of Riboswitch Ligands”, Biochemistry, vol. 61, 2022. [Link]
M. E. Sherlock, Higgs, G., Yu, D., Widner, D., White, N., Sudarsan, N., Sadeeshkumar, H., Perkins, K., G Arachchilage, M., Malkowski, S. N., King, C., Harris, K. A., Gaffield, G. J., Atilho, R. M., and Breaker, R. R., “Architectures and complex functions of tandem riboswitches”, RNA Biol., vol. 19, no. 1, 2022. [Link]

2021

A. Roth, Weinberg, Z., Vanderschuren, K., Murdock, M. H., and Breaker, R. R., “Natural circularly permuted group II introns in bacteria produce RNA circles”, iScience, vol. 24, no. 12, 2021. [Link]
K. I. Brewer, Gaffield, G. J., Puri, M., and Breaker, R. R., “DIMPL: a bioinformatics pipeline for the discovery of structured noncoding RNA motifs in bacteria”, Bioinformatics, 2021. [Link]
K. I. Brewer, Greenlee, E. B., Higgs, G., Yu, D., G Arachchilage, M., Chen, X., King, N., White, N., and Breaker, R. R., “Comprehensive discovery of novel structured noncoding RNAs in 26 bacterial genomes”, RNA Biol, 2021. [Link]
Y. Yang, Harris, K. A., Widner, D., and Breaker, R. R., “Structure of a bacterial OapB protein with its OLE RNA target gives insights into the architecture of the OLE ribonucleoprotein complex”, Proc Natl Acad Sci U S A, vol. 118(9), 2021. [Link]
S. S. S. Panchapakesan and Breaker, R. R., “The case of the missing allosteric ribozymes”, Nat Chem Biol, 2021. [Link]

2020

H. Salvail, Balaji, A., Yu, D., Roth, A., and Breaker, R., “Biochemical Validation of a Fourth Guanidine Riboswitch Class in Bacteria”, Biochemistry, 2020. [Link]
S. S. S. Panchapakesan, Corey, L., Malkowski, S. N., Higgs, G., and Breaker, R. R., “A Second Riboswitch Class for the Enzyme Cofactor NAD”, RNA, 2020. [Link]
D. Yu and Breaker, R. R., “A bacterial riboswitch class senses xanthine and uric acid to regulate genes associated with purine oxidation”, RNA, vol. 26, no. 8, p. 960, 2020. [Link]
R. R. Breaker, “Imaginary Ribozymes”, ACS Chem Biol, vol. 15, no. 8, p. 2020, 2020. [Link]
S. N. Malkowski, Atilho, R. M., Greenlee, E. B., weinberg, C., and Breaker, R. R., “A rare bacterial RNA motif is implicated in the regulation of the purF gene whose encoded enzyme synthesizes phosphoribosylamine”, RNA, 2020. [Link]
M. E. Sherlock and Breaker, R. R., “Former orphan riboswitches reveal unexplored areas of bacterial metabolism, signaling, and gene control processes”, RNA, vol. 26, no. 6, p. 675, 2020. [Link]

Pages